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  • The Business Playbook for Physicians Who Want to Win Beyond the Clinic

    The Business Playbook for Physicians Who Want to Win Beyond the Clinic
    2026/04/21

    You went into medicine to save lives. But somewhere between residency and the real world, you started wondering — is there more I could be doing?

    That question is not a distraction. It might be your next diagnosis, and the biggest obstacle is knowing where to start.

    In this episode, host Dr. Junaid Kalia sits down with Dr. Sara Rana, a physician-turned-venture capitalist and MD-MBA, who saw the gap between healthcare and finance firsthand and built her career bridging it. The conversation moves from her origin story into the practical frameworks, honest realities, and hard-earned wisdom any physician can act on today.

    What You Will Discover:

    - Intro: Dr. Sara’s Origin Story

    - Why Physicians Must Speak Business

    - Charting Her Own Path as Venture Capitalist

    - Inflation, AI & the Forces Reshaping Financial Future

    - Does Race & Gender Matter?

    - 4 Entry Points to Entrepreneurship

    - The Advice That Reframes the Struggle

    [17:23] Does Geography Make or Break You?

    The same disruption reshaping healthcare through AI is exactly why physicians can no longer afford to only speak medicine. This conversation is where that journey begins.

    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Sara Rana, MD, MBA

    💼LinkedIn - https://www.linkedin.com/in/sararana/

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    20 分
  • How Ultrasound Frequencies Enable Early Intervention and Save Lives

    How Ultrasound Frequencies Enable Early Intervention and Save Lives
    2026/04/14
    What if the difference between a late diagnosis and a successful intervention was simply how we decode the signals of a sound wave?In this episode, we are discussing the transition of ultrasound from a static hospital tool to a mobile network of care that brings diagnostics directly to the patient. Dr. Junaid Kalia, Dr. Harvey Castro, and Edward Marx explore a radical shift in medical imaging with Soner, Co-founder and CEO of PONS Tech. By analyzing raw ultrasound frequencies rather than just the visual image, PONS makes visible the early-stage features that are typically invisible on a standard scan. This episode breaks down how we can empower non-specialists—like nurses and caregivers—to perform expert-level scans without disrupting the radiologist's existing workflow.From navigating clinical "dyad" leadership to addressing the financial barriers of the current revenue cycle, we map out how to rebuild a reactive healthcare system into a proactive, community-based signal of care.What You Will Discover:Intro: From Personal Tragedy to a Medical Innovation- Why PONS Focuses on Raw Frequency-Level Dynamics- How the Tech is Scaling Diagnostic Accuracy - On Addressing the Limitations of Mammography- Why Health Systems Must Rethink How We Pay for Prevention- Shifting Health Systems Toward Continuous Preventive Care🎤 Host Spotlight: Ed Marx is keynoting the Northwood University Health Care Summit on April 22. Worth a watch — register here: https://lnkd.in/gSi82Zd8Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamdDr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/🔗Website - https://www.harveycastromd.com/📷Instagram - https://www.instagram.com/harveycastromd/?hl=en📑 Substack - https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼LinkedIn - https://www.linkedin.com/in/edwardmarx/🔗Website - https://www.marxadvisory.com/📹YouTube - https://www.youtube.com/@EdwardMarxSpecial Guest:Soner Hacıhaliloğlu, Co-Founder and CEO of PONS💼LinkedIn - https://www.linkedin.com/in/sonerhaci/Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    18 分
  • The Treatment Exists But Why Aren't Patients Getting It?

    The Treatment Exists But Why Aren't Patients Getting It?
    2026/03/31
    What if the real barrier to better patient outcomes isn't the medicine — it's the infrastructure to prescribe it well?This episode surfaces a broader signal: personalized medicine is no longer a future ambition — it's a present clinical need. And the system, as it stands, is not equipped to deliver it at scale.Joining the conversation are Itay Segal and Dr. Jean-Claude, co-founders of Unlock Healthcare, to explore one of medicine's most underexamined tensions: the gap between what a treatment can do and what the current system is built to support. The discussion centers on cannabinoid medicine — not as a cultural phenomenon, but as a clinical case study for why one-size-fits-all care fails the patients who need personalized treatment most.This episode asks the harder question: before we can treat patients better, do we have the right foundation in place to even try?What You Will Discover:- The Gap Between Need and Treatment- Infrastructure as the Real Innovation- Why One Size Fits No One- The Physician as Informed Partner, Not Just Licensor- The Regulatory Runway- The Evidence GapA note from Signal & SymptomsThis episode doesn't center on AI — and that's precisely the point. Before AI can meaningfully improve patient outcomes, the clinical infrastructure to capture, act on, and learn from patient data has to exist first. What Unlock Healthcare is building is that foundation layer. We separate signal from noise at Signal & Symptoms, and this episode's signal is clear: the future of treatment depends as much on the systems we build around medicine as on the medicine itself.References:🖇️ "DRGPT AI Lessons (3 books)" – https://www.amazon.com/dp/B0GTNQ18K2?binding=paperbackConnect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en 📑 Substack - https://harveycastromd.substack.com/ Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guests:Itay Segal, Co-Founder, CEO at Unlock.Healthcare💼LinkedIn - https://www.linkedin.com/in/itay-segal-723b488/Jean Claude Scicluna, MD, MSc, Co-Founder, Medical Director at Unlock.Healthcare💼LinkedIn - https://www.linkedin.com/in/jeanclaudescicluna/ Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    20 分
  • AI Is In Healthcare—So Why Isn't It Working?

    AI Is In Healthcare—So Why Isn't It Working?
    2026/03/24

    The overarching signal is: we're early, it's messy, and the people closest to the work know it best.

    In this episode, Dr. Andrew Kim joins hosts Dr. Junaid Kalia, Dr. Harvey Castro, and Eward Marx for an unfiltered look at what healthcare AI implementation looks like from the inside. They are diagnosing the vendor translation failures, the physician workflow wars, the governance structures being built in real time, and the looming AI-vs-AI battle between health systems and insurance companies.

    The episode reveals an insider implementer’s perspective on where most AI deployments succeed or fail. Tune in to reflect on where your organization sits on the healthcare AI adoption curve, and what role you play in closing the gap.

    What You Will Discover:

    - The AI Market Diagnosis

    - The Clinician Workflow-Vendor Roadmap Collision

    - AI Governance Inside a Health System

    - Forecast on AI Displacement

    - The “Magic Wand” Round

    - Personalization vs. McDonaldization in Medicine

    Referenced in the show:

    🖇️ "Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout" – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2839542

    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/



    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Andrew Kim, MD, MBA, Director of Physician Informatics, Baylor Scott & White Health

    💼LinkedIn - https://www.linkedin.com/in/andrew-kim-md-mba-65364a4/

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    20 分
  • 71% of FDA-Approved AI May Be a Clinical Liability (Here’s Why)

    71% of FDA-Approved AI May Be a Clinical Liability (Here’s Why)
    2026/03/17

    When 71% of training data for FDA-approved AI comes from just three states, geographic bias shifts from a technical oversight to a direct clinical liability. To deliver on the promise of value-based care, we must move beyond "clean" academic datasets and integrate the diverse, real-world data that reflects the actual patients we serve.

    In this episode, Dr. Junaid Kalia and Dr. Harvey Castro sit down with Dr. Martin Willemink, a radiologist and former Stanford faculty member who transitioned into the entrepreneurial world to solve AI’s most significant bottleneck: data diversity. As a clinician-turned-founder of Segmed, Dr. Willemink provides a systematic look at why "garbage in, garbage out" is a systemic risk to patient safety and how building a more representative data pipeline is the only way to achieve true generalizability in healthcare AI.

    What You Will Discover:

    - Intro: The Data Bottleneck of Healthcare AI

    - Dr. Willemink’s Journey from Stanford faculty to Y Combinator

    -Addressing Data Bias in Clinical Models

    - The Future of Multimodal AI in Healthcare

    - Balancing Data Privacy & Patient Protection

    - Synthetic Data in AI Development

    - 5 Insights for Solving the Data Problem

    Referenced in the show:

    🖇️ "Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms" – https://pmc.ncbi.nlm.nih.gov/articles/PMC7509620/

    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Martin Willemink, MD, PhD, FSCCT, Co-founder & Chief Scientific Officer at Segmed

    💼LinkedIn - http://linkedin.com/in/martin-willemink

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/
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    21 分
  • The Data Problem That Healthcare Can't Ignore

    The Data Problem That Healthcare Can't Ignore
    2026/03/10

    What happens when the data behind AI doesn't actually reflect the patients it's meant to help? And if precision medicine is the goal, what’s truly standing between us and getting there?

    These are not rhetorical questions. They sit at the center of this week's conversation with Dr. Saira Haque, Senior Director of Clinical Informatics at Pfizer Medical Affairs. Together with the hosts, they examine why AI's promise in healthcare keeps encountering the same recurring limitation: fragmented, unrepresentative data that was never built to reflect the full diversity of patients it is meant to serve.

    She argues that getting the data right is where the work begins. But data alone isn't enough. The human-in-the-loop is a non-negotiable. AI doesn't replace clinical judgment; it sharpens it.

    What You Will Discover:

    - Dr. Haque’s Career Journey

    - How She Views Healthcare AI

    - AI as the Latest in a Series of Tech Innovations

    - Keeping Up With the Pace of AI & Regulatory Change

    - AI Won't Replace You. Here's Why

    - Is AI-Developed Medicine Real? Rating the Hype

    - Global Regulatory Alignment on AI

    - Bias & Representational Gaps in Clinical AI Data

    - Synthetic vs. Augmented Data & Digital Twins

    - What Would Fix Healthcare AI Today?

    This episode doesn't offer a tidy roadmap. Yet, it offers something more enduring: a way of thinking about AI that is neither fearful nor naive.



    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Saira Haique, PhD, Lead, Advanced Medical Solutions Group

    💼LinkedIn - https://www.linkedin.com/in/saira-haque-phd-mhsa-famia-achip/


    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/
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    21 分
  • Why Healthcare Leaders Are Still Denying the AI Shift

    Why Healthcare Leaders Are Still Denying the AI Shift
    2026/03/03

    Global anxiety about AI and jobs is at its peak. And the data suggests people are right to feel it. But this episode isn't a warning. It's a diagnosis.

    Dr. Junaid Kalia, Edward Marx, and Dr. Harvey Castro step back from the weekly AI noise to examine the macro trajectory of the era we're actually living through — where five major innovation platforms are converging simultaneously, the cost of intelligence is collapsing, and the gap between technology and human adaptability has never been wider.

    The anxiety isn't irrational. It's a signal. And understanding what it's pointing to is the first step.

    What You'll Discover:

    - The Great Acceleration & The Five Converging Platforms

    - Why Brilliant People Are Still Dismissing AI — And What That Tells Us

    - The Cost of Intelligence Is Collapsing

    - AI in Healthcare: Real Gains, Real Barriers

    - The Human-in-the-Loop Design Challenge


    The future of healthcare isn't about choosing between human and machine—it's a collaboration where technology enhances our capabilities while human judgment and compassion remain at the forefront of patient care.


    Referenced in the show:

    🖇️ AI Healthcare Index by Dr. Harvey Castro – https://drive.google.com/file/d/18f04lD4nKtOmjJqc_J-F9bhbY4NkqZki/view?usp=sharing

    🖇️ Big Ideas Research Report by ARK Invest – https://www.ark-invest.com/big-ideas-2026


    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    20 分
  • How a 200-Year-Old Hospital Is Adapting to an AI-Driven World

    How a 200-Year-Old Hospital Is Adapting to an AI-Driven World
    2026/02/24
    What happens when a 200-year-old safety-net hospital decides it's had enough of losing revenue to insurance denials and uses AI to fight back? The answer may change how you think about the intersection of clinical care and financial sustainability.In this episode, we sit down with Jani Rad, Dr. Kito Lord, and Robin Clanton from Regional One Health in Memphis, Tennessee. Together, they walk us through how a historically under-resourced hospital became an unlikely AI innovator — starting not with flashy technology, but with a simple question: can we just see our own data? From breaking down departmental silos to deploying AI that identifies payer denial patterns, generates appeals in bulk, and surfaces the big-picture revenue opportunities that encounter-by-encounter worklists will always miss — this team is actively building and testing a solution that directly bridges the gap between clinical documentation, finance, and patient outcomes.What You Will Discover:[00:00] Intro[00:52] Meet the Regional One Health Team[03:24] Data as the Starting Point[04:17] The Physician Advisor Program[06:00] First Tiptoe into AI[08:56] Seeing the Big Picture[10:00] From Data to Action[11:39] AI Checks and Balances[13:26] The AI Arms Race[14:28] Negotiating Denials at Scale[18:16] The Why Behind the WorkConnect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamdDr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/🔗Website - https://www.harveycastromd.com/📷Instagram - https://www.instagram.com/harveycastromd/?hl=enEdward Marx, CEO, Advisor💼LinkedIn - https://www.linkedin.com/in/edwardmarx/🔗Website - https://www.marxadvisory.com/📹YouTube - https://www.youtube.com/@EdwardMarxSpecial Guest:Jani Rad, CEO, Regional One Health Solutions💼LinkedIn - https://www.linkedin.com/in/janirad/Kito Lord, MD, MBA, CHCQM-PHYADV💼LinkedIn - https://www.linkedin.com/in/kito-lord-md-mba-chcqm-phyadv-0b2a33a6/Learn more about Regional One Health🔗 https://www.regionalonehealth.org/Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    20 分